Treatment with medications and insulins in a personalized way will avoid weight gain, help improve quality of life, and free from burden of low blood glucose. Several older classes of drugs can actually worsen overweight and obesity in people with type two diabetes. Newer therapies along with judicious use of insulin can help control weight gain that can stymie the best efforts to control Type 2 diabetes. In addition, with changes in lifestyle, nutrition and exercise, it often as possible for people to come off of insulin and other diabetes drugs. Ultimately, people with Type 2 diabetes can have long fulfilling lives where they are not overburdened with their disease and can enjoy family feasts and are able to lose weight when they want to. Diabetes-related distress can stymie attempts to control glucose is. Prior low blood glucose episodes make people less likely to want to control the blood glucose.